“Calculating trabecular bone score can become a new screening instrument, if we get more information on cut off values in different ages and gender.” Dr Neumann, who presented the findings at the meeting, said studies have shown that patients with type 1 diabetes have a higher risk for fracture than those without diabetes. Clipboard, Search History, and several other advanced features are temporarily unavailable. Front. This meta-analysis showed that compared with controls, diabetic patients had a lower trabecular bone score (TBS) than non-diabetic individuals, suggesting that TBS can be a useful measurement for the assessment of fracture risk in diabetic patients. Joint Bone … In contrast to 72% of patients with PHPT showing degraded or partially degraded microarchitecture by TBS, only 46% were classified as osteopenic or osteoporotic by lumbar spine T-score. Shayganfar A, Ebrahimian S, Masjedi M, Daryaei S. J Res Med Sci. The findings of the study suggest a different role of t rabecular and cortical volumetric BMD on coronary artery calcification risk, mainly in women.. Utility of trabecular bone score in the evaluation of osteoporosis. It was developed to reflect bone microarchitecture. The study was approved by the institutional review board of CUMC, and all subjects gave written informed consent. Boutroy S , Van Rietbergen B , Sornay-Rendu E , Munoz F , Bouxsein ML , Delmas PD. The results of this study show, for the first time, significant correlations between TBS and HRpQCT measurements of volumetric densities, skeletal microarchitecture, and bone stiffness at the radius and tibia in a group of postmenopausal women with PHPT. Hansen et al (6) have also observed similar structural deficits at the distal radius in PHPT. Patients with type 2 diabetes have an increased risk of fracture despite having a higher areal bone mineral density. Trabecular bone score (TBS), a novel tool in the evaluation of osteoporosis is an indirect indicator of bone microarchitecture. . Khosla S , Riggs BL , Atkinson EJ , et al. To this end, our aim was to assess TBS from spine DXA images in postmenopausal women with PHPT and to correlate it, for the first time, with HRpQCT measurements of volumetric bone density, skeletal microarchitecture, and bone stiffness. These deficits are associated with reduced whole bone and trabecular stiffness by finite element analysis (FEA) (7). Article Google Scholar 3. Sweden: T rabecular and cortical volumetric bone mineral density (BMD) have opposite association with coronary-artery calcium score (CACS), suggests a recent study in the journal JAMA Cardiology. Bilezikian JP , Brandi ML , Rubin M , Silverberg SJ. Unlike regular XR, in which it’s possible to assess the trabecular structure, DEXA’s low radiation is not enough for trabeculae differentiation. Likewise, although our results showed positive relationships between TBS and whole bone stiffness at the radius and tibia, no significant correlations between TBS and trabecular stiffness were observed either at the radius or at the tibia, even after adjustment for body weight. In contrast, the trabecular bone score is a novel and widely available tool that uses gray-scale variograms of the spine image from dual-energy x-ray absorptiometry to assess trabecular quality. In clinical studies, TBS enhanced the ability of DXA to predict fracture risk (15–20), and in a recent study involving more than 29,000 postmenopausal women, TBS predicted osteoporotic fractures, independent of aBMD (20). Leslie WD, Shevroja E, Johansson H, McCloskey EV, Harvey NC, Kanis JA, Hans D. Osteoporos Int. Using AP spine data obtained during routine DXA exams, TBS iNsight™ produces a clinically significant 1,2 fracture risk parameter. A recently developed diagnostic tool, trabecular bone score (TBS), can provide quality of trabecular microarchitecture based on images obtained from dual-energy X-ray absorptiometry (DXA). Data are means ± SEM. Since patients receiving glucocorticoid are at a higher risk of developing secondary osteoporosis, assessment of bone microarchitecture may be used to evaluate risk of fragility fractures of osteoporosis. Site-matched spine TBS parameters were extracted from the DXA image using TBS iNsight software (version 1.9; medimaps, Geneva, Switzerland). A procedure to generate TBS-adjusted FRAX probabilities has become available with the resultant predicted fracture risks shown to be more accurate than the standard FRAX tool. A Spanish case-control study, Bone mineral density (BMD) combined with the trabecular bone score (TBS) significantly improves the identification of women at high risk of fracture: the SEMOF Cohort Study [abstract], Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study, Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study, What is the performance in vertebral fracture discrimination by bone mineral density (BMD), micro-architecture estimation (TBS), body mass index (BMI) and FRAX in stand-alone or combined approaches: The OsteoLaus Study [abstract], Spine micro-architecture estimation (TBS) discriminates major osteoporotic fracture from controls equally well than site matched BMD and independently: the Eastern Europe TBS study [abstract], In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography, Comparison of 2D and 3D bone microarchitecture evaluation at the femoral neck, among postmenopausal women with hip fracture or hip osteoarthritis, Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment, High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone, Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method, Primary hyperparathyroidism: iliac crest trabecular bone volume, structure, remodeling, and balance evaluated by histomorphometric methods, Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism, Bone structure in postmenopausal hyperparathyroid, osteoporotic, and normal women, Maintenance of cancellous bone connectivity in primary hyperparathyroidism: trabecular strut analysis, The histomorphometry of bone in primary hyperparathyroidism: preservation of cancellous bone structure, Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy, Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality, Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women, Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures, Identification of rheumatoid arthritis patients with vertebral fractures using bone mineral density and trabecular bone score, TBS (trabecular bone score) and diabetes-related fracture risk, Bone quality, as measured by trabecular bone score in patients with adrenal incidentalomas with and without subclinical hypercortisolism, Effects of zoledronate versus placebo on spine bone mineral density (BMD) and microarchitecture assessed by the trabecular bone score (TBS) in postmenopausal women with osteoporosis. Curr Osteoporos Rep 9(3):112–115 . There are no studies assessing whether trabecular bone score characterizes bone quality in kidney transplant recipients. Therefore, this cross‐sectional study investigated the association between TBS and severe periodontitis. INTRODUCTION:Trabecular bone score (TBS) is a textural index that evaluates bone microarchitecture of the lumbar spine. Bone texture; Dual-energy X-ray absorptiometry; Fracture; Osteoporosis; Trabecular bone score. INTRODUCTION:Trabecular bone score (TBS) is a textural index that evaluates bone microarchitecture of the lumbar spine. At the tibia, TBS was a poor predictor of the variance in HRpQCT measurements of trabecular microarchitecture. The association between type 2 diabetes and trabecular bone score (TBS) has not been clear. Article Google Scholar 2. 2018 Jul;30(4):412-419. doi: 10.1097/BOR.0000000000000504. Statistical analysis was performed using SAS (version 9.2; SAS Institute, Inc, Cary, North Carolina). For each finite element model, a uniaxial compression test was performed with displacement equivalent to 1% apparent strain to calculate stiffness. 2020 Dec 1;8(4):49. doi: 10.3390/medsci8040049. TBS measurements were performed in the Bone Disease Unit at the University of Lausanne (Lausanne, Switzerland), using deidentified spine DXA files from scans obtained at CUMC. TBS iNsight est dérivé de l’évaluation du variogramme, expérimentale, obtenue à partir des niveaux de gris de l’ image DXA . 23 TBS is a bone texture parameter that quantifies cancellous bone microarchitecture, which is key in determining bone strength and resistance to fracture, by computing raw data from a dual energy X‐ray absorptiometry (DXA) image of the lumbar spine. 2020 Oct;10(10):2066-2077. doi: 10.21037/qims-2020-16. Trabecular bone score (TBS), as a tool for measurement of bone microarchitecture, represents fracture risk independently of bone density. The trabecular bone score (TBS) is a textural measurement derived from lumbar spine d ual-energy X-ray absorptiometry (DXA) images. Chinese expert consensus on the diagnosis of osteoporosis by imaging and bone mineral density. Roux JP , Wegrzyn J , Boutroy S , Bouxsein M , Hans D , Chapurlat R. Pothuaud L , Barthe N , Krieg MA , Mehsen N , Carceller P , Hans D. Rabier B , Heraud A , Grand-Lenoir C , Winzenrieth R , Hans D. Winzenrieth R , Dufour R , Pothuaud L , Hans D. Del Rio LM , Winzenrieth R , Cormier C , Di Gregorio S. Popp A , Meer S , Krieg MA , Perrelet R , Hans D , Lippuner K. Hans D , Goertzen AL , Krieg MA , Leslie WD. Disclosure Summary: D.H. is a co-owner of the patent for TBS. Therefore, this cross‐sectional study investigated the association between TBS and severe periodontitis. Because BMI is taken into account in the calculation of the TBS, part of the variability in HRpQCT measurements explained by TBS alone might depend on some interaction of TBS with weight. Low trabecular bone score (TBS) is associated with new bone formation independent of fat metaplasia on spinal MRI in patients with ankylosing spondylitis (AS), according to study results published in Scandinavian Journal of Rheumatology.. Trabecular bone score (TBS; expressed as Z-scores) in control subjects and in all patients with primary hyperparathyroidism (PHPT) at baseline, in 20 surgically treated patients with PHPT at baseline and after a 24-month follow-up and in 10 conservatively followed up patients with PHPT at baseline and after 24 months. But, is DEXA adequate for this task? Cheng X, Yuan H, Cheng J, Weng X, Xu H, Gao J, Huang M, Wáng YXJ, Wu Y, Xu W, Liu L, Liu H, Huang C, Jin Z, Tian W; Bone and Joint Group of Chinese Society of Radiology, Chinese Medical Association (CMA), Musculoskeletal Radiology Society of Chinese Medical Doctors Association, Osteoporosis Group of Chinese Orthopedic Association, Bone Density Group of Chinese Society of Imaging Technology, CMA*. The other authors have nothing to disclose. Citation: Ruaro B, Casabella A, Paolino S, Alessandri E, Patané M, Gotelli E, Sulli A and Cutolo M (2020) Trabecular Bone Score and Bone Quality in Systemic Lupus Erythematosus Patients. Thangavelu T, Silverman E, Akhter MP, Lyden E, Recker RR, Graeff-Armas LA. Significant correlations between TBS and 3D direct measurements of trabecular microstructure were previously observed in human cadaver bone specimens (vertebrae, femur, and radius) (12, 13). Perimenopausal women with higher baseline levels of serum bone turnover markers and a lower trabecular bone score are at increased risk for presenting with osteopenia or osteoporosis at 5 … These results also need to be followed up with a larger number of patients along with 2 groups of hyperparathyroid subjects we have yet to study, namely men and premenopausal women. When TBS is combined with bone density testing, we learn more about your bone health than with bone density testing alone. The trabecular bone score (TBS) is a new method to describe skeletal microarchitecture from the dual energy X-ray absorptiometry (DXA) image of the lumbar spine. Linear regression analyses, without and with adjustment for weight, were applied to estimate the variability in HRpQCT and biomechanical parameters when TBS, aBMD at the lumbar spine, or the combination of both was used as the explanatory variable. The trabecular bone score (TBS) a grayscale measurement of texture which is derived from the evaluation of the experimental variogram obtained from the Dual-energy X-ray Absorptiometry (DXA) images, is a relatively new tool to evaluate bone microarchitecture . . Because of the relatively small number of subjects, we could not evaluate any association between TBS and fracture risk in PHPT. It was proposed to be easily used in everyday practice as a surrogate of bone strength. TBS is related to bone microarchitecture and provides skeletal information that is not captured from the standard bone mineral density (BMD) measurement. The Trabecular Bone Score is computed from the antero-posterior spine DXA examination file by a software (TBS iNsight) that is provided for use as a complement to a DXA analysis. Trabecular bone score and transilial bone trabecular histomorphometry in type 1 diabetes and healthy controls. Intact PTH (normal, 14–66 pg/mL) was measured by immunoradiometric assay (Scantibodies Laboratory, Santee, California) in the Bone Marker Laboratory at CUMC. Using cutoff points previously reported as having the best sensitivity and specificity in terms of fracture risk (19–23), we showed that 36% of patients with PHPT had degraded microarchitecture (TBS ≤1.20), an additional 36% had partially degraded microarchitecture (TBS >1.20 and <1.35), and only 27% had normal TBS values (TBS ≥1.35). The Trabecular Bone Score is a rather new index obtained at the lumbar spine at the same time as a real bone mineral density. With the use of linear regression analysis, TBS or L1–L4 aBMD alone explained 20 to 52% of variance in HRpQCT measurements of volumetric densities, Ct.Th, BV/TV, and whole bone stiffness at the radius and tibia. Twenty-two postmenopausal women with PHPT were recruited from Columbia University Medical Center (CUMC). Citation: Ruaro B, Casabella A, Paolino S, Alessandri E, Patané M, Gotelli E, Sulli A and Cutolo M (2020) Trabecular Bone Score and Bone Quality in Systemic Lupus Erythematosus Patients. TBS predicts osteoporotic fractures independently of BMD 3,4. Trabecular bone score (TBS) is a novel gray-level textural analysis that can be applied to DXA images to estimate trabecular microarchitecture and has been shown to be related to direct measures of bone microarchitecture and fracture risk (12). aBMD by DXA was measured at the lumbar spine (L1–L4), total hip, femoral neck, and nondominant forearm (ultradistal [UD] radius and one-third radius) using a Discovery A dual-energy X-ray absorptiometer (Hologic Inc; Bedford, Massachusetts). Barbara Campolina Silva, Stephanie Boutroy, Chiyuan Zhang, Donald Jay McMahon, Bin Zhou, Ji Wang, Julia Udesky, Serge Cremers, Marta Sarquis, Xiang-Dong Edward Guo, Didier Hans, John Paul Bilezikian, Trabecular Bone Score (TBS)—A Novel Method to Evaluate Bone Microarchitectural Texture in Patients With Primary Hyperparathyroidism, The Journal of Clinical Endocrinology & Metabolism, Volume 98, Issue 5, 1 May 2013, Pages 1963–1970, https://doi.org/10.1210/jc.2012-4255. In this study, the researchers aimed to evaluate the association between TBS and new bone formation independently of fatty lesions on spinal MRI, both …  |  It is a simple, rapid and reproducible method that seamlessly integrates into your workflow and estimates fracture risk based on determination of bone texture. Christiansen P , Steiniche T , Vesterby A , Mosekilde L , Hessov I , Melsen F. Dempster DW , Muller R , Zhou H , et al. . Correlations adjusted for body weight between TBS and trabecular number (A and C) and whole bone stiffness (B and D) at the radius/tibia. The aim of this study was to estimate the reference values of TBS in both genders among the Iranian population to evaluate osteoporotic fractures in the future. Carter S, Lories RJ (2011) Osteoporosis: a paradox in ankylosing spondylitis. TBS, a measurement technology readily available by DXA, shows promise in the clinical assessment of trabecular microstructure in PHPT. Red bone marrow, where all the blood cells are made, fills the space between the trabecular pores. The result is expressed as a Trabecular Bone Score. The correlation of TBS with HRpQCT indices, mechanical parameters, and DXA measurements was assessed by the Pearson correlation test. Women were considered postmenopausal if they had not had a menstrual period for more than 1 year. Curr Opin Rheumatol. It is a textural index that evaluates pixel gray-level variations in the lumbar spine DXA (dual energy X-ray absorptiometry) image. Whereas HRpQCT has added a dimension of insight not previously seen with regard to trabecular bone in PHPT, HRpQCT is not widely available and remains so far a research tool. But, is DEXA adequate for this task? The trabecular bone score (TBS) is a gray‐level textural metric that can be extracted from the two‐dimensional lumbar spine dual‐energy X‐ray absorptiometry (DXA) image. Trabecular bone, also called cancellous bone, is porous bone composed of trabeculated bone tissue.  |  Sweden: T rabecular and cortical volumetric bone mineral density (BMD) have opposite association with coronary-artery calcium score (CACS), suggests a recent study in the journal JAMA Cardiology. Using electronic and manual search, we identified 12 studies that had examined the association between type 2 diabetes and TBS between … 2020 Jul 25;21(1):299. doi: 10.1186/s12882-020-01944-0. Page 2 of 2 . Only 3 (14%) patients were classified as osteoporotic and 7 (32%) as osteopenic, whereas the remaining 12 (54%) subjects presented with normal L1–L4 T-scores by DXA. Boutroy S , Bouxsein ML , Munoz F , Delmas PD. However, part of this correlation was partially confounded with age. Recently, the trabecular bone score (TBS) has been introduced as a novel tool for assessing bone microarchitecture. Univariate or Multivariate Linear Regression Analysis to Predict the Variability in HRpQCT Indices and Mechanical Parameters. The average creatinine clearance was normal at 77.7 mL/min per 1.73 m2. 2017. Similarly, in the study of Boutroy et al (21), nonosteoporotic women whose TBS values were less than 1.209 (the first TBS quartile threshold) had a significant higher incidence of fragility fracture. Trabecular Bone Score (TBS) Trabecular Bone Score (TBS) is measured from a lumbar spine DXA image and thus no extra scan is required. Association of Low Serum 25OHD Levels with Abnormal Bone Microarchitecture in Well-Differentiated Thyroid Cancer. The association between systemic bone loss and periodontitis remains unresolved; and the trabecular bone score (TBS) is a new index for assessing decreased bone quality. Effects of cocoa-rich chocolate on cognitive performance in postmenopausal women. TBS® performs a gray level analysis (textures) on the DEXA images to determine bone integrity. After this observation, TBS was derived from DXA images of lumbar vertebrae, and significant correlations between trabecular indices by μCT and TBS were confirmed (13, 14). Curr Opin Endocrinol Diabetes Obes. Methods. Nevertheless, there may be a tendency for higher correlations between these 2 indices when Hologic scanners (21, 42) as opposed to GE Lunar DXA devices (20, 43) are used. Shevroja E, Lamy O, Kohlmeier L, Koromani F, Rivadeneira F, Hans D. J Clin Densitom. 1. 3D-analysis of cortical and trabecular bone from hip DXA is a new method for non-invasive bone structure assessment, providing separate assessment of the cortical layer and trabecular macrostructure. Methods . Search for other works by this author on: The study of hyperparathyroidism at the Massachusetts General Hospital, The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years, A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery, Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features, Skeletal disease in primary hyperparathyroidism, Effects on bone geometry, density, and microarchitecture in the distal radius but not the tibia in women with primary hyperparathyroidism: A case-control study using HR-pQCT, Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women, Primary hyperparathyroidism and the risk of fracture: a population-based study, Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism, Increased mortality and morbidity in mild primary hyperparathyroid patients. Serum N-Mid osteocalcin (OC) (IDS, Scottsdale, Arizona), bone-specific alkaline phosphatase (BSAP) (Quidel, San Diego, California), and C-telopeptide (CTX) (IDS) were measured by ELISA. Bone mineral density was expressed in grams per square centimeter and in T-score unitage. Several salient observations have emerged. Oxford University Press is a department of the University of Oxford. Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. The reason for these discrepant findings is still not clear but is probably related to the image resolution, the DXA soft tissue correction applied, and the spectra of X-ray energies used. Patients with MGUS have increased cortical porosity and decreased bone strength as measured by HRpQCT imaging. The findings of the study suggest a different role of t rabecular and cortical volumetric BMD on coronary artery calcification risk, mainly in women.. Leslie WD , Aubry-Rozier B , Lamy O , Hans D. Eller-Vainicher C , Morelli V , Ulivieri FM , et al. Descriptive statistics are expressed as means ± SEM. Red bone marrow, where all the blood cells are made, fills the space between the trabecular pores. The utility and limitations of using trabecular bone score with FRAX. Hawkins Carranza F, Guadalix Iglesias S, De Mingo Dominguez ML, Allo Miguel G, Arroba CM, Alvares BL, Martínez Diaz-Guerra G. Med Sci (Basel). A TBS threshold of 1.200 has been used in numerous studies to identify patients at high risk of fracture. To ensure comparability with previous TBS studies, calibration of the DXA instrument at CUMC was performed using a TBS-specific phantom (medimaps).